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STUDENT DIGITAL NEWSLETTER ALAGAPPA INSTITUTIONS |
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Christopher Whaley PhD
https://publichealth.berkeley.edu/people/christopher-whaley/
Our service provides referrals to attorneys like you in 41 counties (check our Web site for a list of the eligible counties) symptoms before period purchase 3ml careprost with amex. Proof of malpractice insurance in the minimum amount of $100 medicine of the prophet buy careprost 3ml free shipping,000 is required of all participants treatment 0 rapid linear progression 3 ml careprost for sale. He has served as the lead trial attorney in over 140 jury trials treatment rosacea order 3 ml careprost amex, and teaches trial advocacy skills to hundreds of trial lawyers each year medicinenetcom cheap 3 ml careprost amex. When you watch something unfold for the first time symptoms of the flu careprost 3ml on line, it has a sense of urgency and excitement: "Will it end safely? The events N you describe in court may have happened weeks, months, or years before. When you stand to deliver your opening, you already know all of the ins and outs of the case. To your left, stopped at a red light, sits Officer Ron Jones, a 16-year veteran of the Jupiter police department. He drives into the intersection at almost 65 miles per hour nearly 20 miles per hour faster than the speed limit posted to your right. The front left corner of the Expedition slams into the passenger side of his patrol car. Finally, both vehicles run out of energy and come to a complete stop in the middle of the intersection. Every sentence was in the present tense: · "Overhead, you see the eastbound lights on Indiantown Road change from green. These individuals have provided an important public service to the poorest, the most vulnerable and the weakest in our society. She now informs me that she has been diagnosed as bi-polar, and she is being held in a state mental institution. A guardian has been appointed by the court of that state to take control of her property and assets. She has been getting money from a trust set up in New York by her late father, pursuant to which an annuity was created to give her monthly payments for life. She called me on the phone to ask if she could direct the Nebraska insurance company to send future monthly payments to me. I would set up a New York escrow account to be turned over to her at an appropriate later time. Would this be considered an evasion of the foreign state order which specifies that her assets and property be taken over by the guardian? I think future payments which originate in Nebraska pursuant to a New York trust and which never reach the foreign state may be excluded. Is my giving of telephone advice possibly be considered practicing law in the foreign state? I am uneasy about what may be be considered an attempt to thwart the order of a foreign court. If she has been, or shortly may be, adjudicated an incompetent, how will you be able to justify carrying out her instructions, even if the foreign court has no jurisdiction over you? Historically, legal employers have been steadfastly and notoriously reluctant to change the way business "has always been done" despite a growing outcry from associate attorneys struggling to balance their professional and personal lives. Requests for flexible work schedules, more varied networking opportunities, and alternate methods of determining compensation have generally been ignored, or granted in theory, but not enforced in practice. As the ranks of entry-level attorneys become increasingly more diverse, and women represent over 50% of the attorneys in the "pipeline" of new graduates, the refusal to consider such requests for change has disparately impacted women and minority attorneys. The predictable result has been a dramatic under-representation of women in the partnership ranks and the exodus of women and minorities from the profession altogether. In recent years, as Generation "X" and "Y" law graduates have entered the workforce in increasing numbers, attrition rates have skyrocketed, as has the corollary cost of recruiting and training new lawyers to replace those who leave in search of greener pastures. The reason for this phenomenon is simple: the values and traditional lifestyles of those at the top of the legal field contrast starkly with those of recent law graduates, both men and women. Yet, the economic impact of the high associate turnover alone has been insufficient to cause legal employers to re-evaluate the way that things have always been done. Over the past year, however, the economic impact of their failure to adapt to changing times has been brought the Attorney Professionalism Committee invites our readers to send in comments or alternate views to the responses printed here, as well as additional hypothetical fact patterns or scenarios to be considered for future columns. Fact patterns, names, characters and locations presented in this column are fictitious, and any resemblance to actual events or to actual persons, living or dead, is entirely coincidental. These columns are intended to stimulate thought and discussion on the subject of attorney professionalism. They are not official opinions on ethical or professional matters, nor should they be cited as such. It is perfectly all right to give friendly advice gratis on the telephone, but do not purport to advise on the laws of another state where you are not admitted. At last, the potential loss of these core clients, combined with the increased costs associated with high attrition rates, has caused many employers to sit up and take notice. Those poised at the upper echelons of the legal field would be well advised to embrace change and take advantage of the newfound flexibility offered by technologic advancements. Your clients will be satisfied, your associate attorneys will be newly content, thus reducing the costs created by high attrition rates, and your profit margins will increase. Management is so strongly averse to litigation that, in my experience, this company will take a substantial loss rather than litigate even when it is clearly in the right. On occasion, my suspicion that certain lawyers are refusing to discuss settlement because they simply want to maximize their own billings has been confirmed by the attorneys themselves. Of course, when we get before a judge, the judge also attempts to expedite a settlement, but such efforts can be thwarted by counsel who insist that their client believes right is on his side. I believe Ethical Considerations, if not Disciplinary Rules, are being violated in such circumstances, but am unsure as to what I can do. That "older" lawyer who corrected your usage must have been substantially older to have alerted you to its presence. The words lie and lay have become a shibboleth that entitles you to membership in a small, elite group. But that membership may convey advantages other than a sense of superiority, so here is an explanation about the rule. Beginning with the easy part of the explanation, there is no problem with the intransitive verb lie when it means "tell a falsehood. For example, you can lay a book on the table, you laid it there yesterday, and you may have laid the book on the same table last Tuesday. To increase the confusion, the past tense of lie is lain, which differs only in its final letter from the past tense of lay. The result of this similarity in spelling and in meaning is that most people do not distinguish the two verbs. By a large majority, even well-educated people choose lay, ignoring the irregular verb lie. At this law school, when the weather is pleasant, one hears plans of "laying out in the sun. But during the Middle English period, modern lie had become lien, while modern lay had become laien perhaps having confused English speakers ever since the 11th century! It would be a shame to think that this mild knee-capping antic is no longer available. A young veterinarian, having observed this woman previously on board, thought that perhaps he could be of assistance and decided to respond. When he arrived at her stateroom to offer his services, however, he found that he was too late. From the Mailbag: Sometime ago a reader questioned me about the meaning of the phrase "in the event," which he has frequently seen in articles in the New Yorker magazine. The quotation he cited for this particular usage was, "The tangled diversity of faith is, in the event, no obstacle for Hitchens. I answered that unless the phrase was a variant usage of "in any event," I could not guess without seeing the larger context in which it appeared. The questioner then wrote to the New Yorker magazine for an explanation, but reports he has received no response. She is the author of Effective Legal Writing (Foundation Press) and co-author of Judicial Opinion Writing (American Bar Association). To create an acronym, take the first letter from a series of words to form a pronounceable word that stands for something. Example of a question mark in the original: the judge asked, "How long will you cross-examine this wit- emphatic declaration, or interjection. Example of an exclamation point in the original: the judge said, "Stop screaming at the witness! Newspapers and magazines omit the periods from common abbreviations to save space. Use a question mark at the end of a direct question, or one to which you expect an answer. Examples: "Would everyone in the courtroom please check in with the court officer. Use an exclamation point at the end of a command, told her to rewrite her brief because it was "ungrammatical and incomprehensible trash"! Exclamation points may accompany mimetically produced sounds: "All night long, I heard the dogs woof! Use exclamation points for informal writing, like birthday wishes to a loved one or the occasional informal e-mail. Instead of using exclamation points to intensify your writing, use concrete nouns and, even better, vigorous verbs. Incorrect: "Dear Joe:" becomes "Dear Joe," Separate hours from minutes with a colon. Example: "Advanced Judicial Opinion Writing: A Handbook for New York State Trial and Appellate Courts. Example: "Lawyer: An individual with a briefcase who can steal more than a hundred men with guns. Example of an independent clause introducing a list: "The defendant asserted three defenses: insanity, extreme emotional disturbance, and self-defense. Incorrect: "The area codes she calls most often are: (212), (718), (917), and (646). Examples: "The judge gave her a useful suggestion: Evaluate a case before you accept a client. Examples: "The judge gave her a useful suggestion: to evaluate the merits of a case before accepting a client. Example: She described her legal career as a "roller-coaster ride": some successes, some failures, and everything in between. Incorrect: "While we were waiting in court; the defendant attacked the prosecutor. Use semicolons, not commas, to separate two independent clauses if the second independent clause begins with a conjunctive adverb ("accordingly," "again," "also," "besides," "consequently," "finally," "for example," "furthermore," "hence," "however," "moreover," "nevertheless," "on the other hand," "otherwise," "rather," "similarly," "then," "therefore," "thus"). Example: "The judge told his law clerk to evaluate the merits of the case; he therefore told his law clerk to prefer logic to emotion. Use semicolons to replace commas and coordinating conjunctions ("and," "but," "for," "nor," "or," "yet"). Examples: "John Doe takes a week to pick a jury; James Roe, his partner, takes an hour to pick a jury. Example: "Lawyer F lost the case (his tenth loss in 12 months); this year he might not get a bonus. Example: the judge told the defendant,"I want to make sure you never get out of jail"; thus, he sentenced the defendant to life without parole. They also set off explanations, interruptions, or phrases that obscure the main text. If the parentheses appear at the end of a sentence, punctuate after the final parenthesis. If the parentheses contain an independent clause, punctuate inside the final parenthesis. Example of parentheses at the end of a sentence: "Lawyers must read carefully (and write carefully). In a quotation that contains a factual, spelling, or usage error, use "[sic]," meaning "thus," after the error. Use brackets in a quotation to show alterations or additions to a letter or letters in a word. Incorrect: the court found that Defendant failed "to substantiate her affirmative defense [by a preponderance of the credible evidence]. According to the Tanbook, use brackets to add information like years and names of courts. Example of spacing between a parentheses and a bracket (Bluebook example): Judith S. Original quotation: "A lawyer with his briefcase can steal more than a hundred men with guns. Apfelroth Pablo David Arredondo Robin Amelia Arzon Arica Dawn Aylesworth Daniel Backenroth Joseph Anthony Baranello Steven Richard Barnett Brian P. Barrett Michael David Battaglia Aaron Matthew Beim Andrey Belenky Nicole Marie Beliveau Leonard Berkowitz Joshua Adam Beser Kristie Blase Ashleigh Lauren Blaylock Nora Bojar Alicia Ann Bond Nicholas James Bragg Katherine Anne Brodsky Susan Friedman Bruno David Andrew Byrne Alexandra Bystritskaya Ioana Calin Sean Phillip Cameron Cody S. Campbell Laurie Ann Centeno Catherine Paskoff Chang James Chang Karen Ken Yen Chao Jean Chen Susan Anne Chen Karen Marie Cherrington Mark Joseph Chorazak Laura Ann Chubb William Armstrong Clareman Michael Squillace Cleary Jack Daryl Cohen Michele Alexandra Cohen Chauncey David Cole Tara Lynn Collins Michele Connolly Matthew Gregory Conroy Jessica Leigh Lopez Cortez Vittorio Cottafavi Kalisha Morgan Crawford Elizabeth Nan Crowe Michael Benjamin Cubell Amy Elizabeth Davis Jesse A. Devine Peter Alexander Devonshire Daniel Diaz Ali Donat Patrick Michael Dowd Laura E.
He was diagnosed with diabetes mellitus (Type 1 or 2 was not specified) with a blood glucose of 290 mg/dL (normal < 100 - 120) symptoms 1 week after conception order 3 ml careprost with mastercard. In the second serious event case symptoms acid reflux careprost 3ml low cost, a 38 year old male was reported to have been diagnosed with drug-induced cholestatic hepatitis after having taken methyl masterdol and methyl 1-D (no longer marketed) medications like zoloft buy careprost 3ml mastercard, both reported by the manufacturer to contain anabolic "prohormones" that are converted to testosterone symptoms 7dpiui purchase 3ml careprost otc, intermittently for most of the 3 month period prior to the event symptoms 7 days after implantation careprost 3 ml free shipping. Although there appears to be a temporal relationship between initiation of creatine supplementation 13 symptoms 6 weeks pregnant careprost 3 ml. A 26 year old male was treated in a military facility in Afghanistan after experiencing a thalamic hemorrhagic stroke less than 12 hours after taking a "performance enhancing" supplement and completing weight lifting training (Young et al. It is unclear if this was the first dose of the product, which contains numerous ingredients, among these caffeine and another sympathomimetic, 1,3-dimethylamylamine. A 24 year old man diagnosed with acute kidney injury reported having taken 52 different dietary supplements during the prior 6 months, including 5 g of creatine three times a week (Thorsteinsdottir et al. Although the authors stated that they found creatine to be the only nephrotoxic substance among the supplements, it is not possible based on the available information to establish whether a causal link with creatine exists. There were a total of 139 reports found, including four deaths due to pneumonia, cardiac arrest (n=2) and a traffic accident, respectively. These cases were reported in association with consumers who used creatine supplementation products marketed for improvement of athletic performance. Frequently reported adverse events included seizures, renal disorders, dyspnea, and rash. There were eight reports in which creatine was reported as the only supplement or medication taken. These cases did not include reports of renal toxicity and do not appear to have any clinical commonalities. No cases reported use in patients with mitochondrial disorders or creatine deficiency syndromes. Clinical trials assessing safety No studies were found specifically designed to assess the safety of creatine in patients with mitochondrial disorders or creatine deficiency syndromes. Increased appetite and mild weight gain were reported by one patient during creatine treatment and one patient during placebo treatment. Long term supplementation with creatine monohydrate is reported to have been well tolerated (Stockler-Ipsiroglu et al. Creatine is generally considered to be safe in humans and common adverse events include minor weight gain and gastrointestinal distress (Persky and Brazeau 2001). Hepatic function has been monitored in various studies and significant abnormalities have not been reported (Juhn and Tarnopolsky 1998). However, use of creatine to enhance athletic performance became associated with a number of significant renal toxicity events, beginning with the deaths of three American college wrestlers in the late 1990s. No confirmation of a causal relationship was identified in the literature search conducted for this review. Subsequent to the three weight loss cases, Pritchard and Kalra (1998) reported that a 25 year old male with an eight year history of focal segmental glomerulosclerosis, and frequently relapsing steroid-responsive nephrotic syndrome that had been minimized with cyclosporin treatment for the previous five years, experienced a substantial decline in renal function over approximately a four month period. The patient reported having taken creatine beginning in mid-August at a dose of 5 g three times a day for one week, followed by 2 g per day for the next seven weeks until he was seen by his physicians in October. One month later, his serum creatinine had dropped to 128 µmol/L and his creatine clearance was 115 mL/min. While the dose and duration of treatments in various animal studies and human case reports and studies differ greatly, in general, doses of approximately 2 5 g/day over a period of months do not appear to be associated with renal toxicity in patients 14. The authors state in their conclusion that elderly patients and patients with Type 2 diabetes, who have normal renal function, may also use creatine safely at these doses. A risk assessment based on a similar evaluation of the published literature recommends a dose limit of 5 g/day for chronic supplementation. Use at higher doses or longer durations, and studies in special populations including children, adolescents, pregnant women, geriatric patients, individuals on high protein diets, and those with disease states that may affect renal function, have not been adequately studied (Gualano et al. This 18 year old male had experienced previous episodes of cerebral stroke and recurrent seizures and had preexisting nephropathy. Although his neurologic symptoms improved, his renal insufficiency worsened over the treatment period, with increasing urea retention and impaired creatinine clearance. Because the decline in renal function occurred gradually, the authors felt that the deterioration was due to the natural course of his underlying disease rather than creatine use. However, they caution that creatine supplementation should be used with caution in mitochondrial disease patients who have preexisting nephropathy. Pharmacokinetic data In a 2007 review of the pharmacokinetics of creatine, McCall and Perksy report that "very little is known about the disposition of creatine after supraphysiologic doses" in humans. Absorption from the gastrointestinal tract in humans is thought, based on animal data, to involve transporters that mediate flux through the intestinal wall. The portion of an administered oral dose that is absorbed has not been established. Gastrointestinal absorption may be limited for a number of reasons: degradation of creatine in the acidic gastric pH, degradation due to gut bacteria, limits in transportation across the intestinal wall, or factors related to dosage form. In a comparison of the ingestion of creatine from various sources, Cmax was found to be higher from a 2 g creatine dose delivered in an oral solution than from 2 g of creatine in meat (Harris et al. In a study of six healthy males, a dose of 71 mg/kg was given for six days and pharmacokinetics were assessed after a single dose and at steady state (Persky et al. In addition to plasma measurements, microdialysis was used to assess the creatine content of interstitial muscle space. A creatine transporter (CreaT) has been identified using in vitro, nonclinical and ex vivo human models and is responsible for cellular uptake of creatine in humans (Snow and Murphy 2001; Snow and Murphy 2003). Transporter activity is influenced by total creatine content, various hormones such as thyroid and insulin, and exercise (Persky et al. CreaT has been shown to be diminished in heart failure and various myopathies, although no studies have established specifics for mitochondrial diseases (Tarnopolsky and Beal 2001). Excess creatine is cleared through renal elimination at a rate that is close to glomerular filtration rate (Pitts 1934). The authors concluded that short term oral creatine supplementation does not affect urinary creatinine, pH or specific gravity values. No information was found regarding the pharmacokinetics of creatine in patients with mitochondrial disorders or creatine deficiency syndromes. Conclusions: Creatine is commonly associated with non-serious events, such as nausea, and safe doses have been identified for healthy adults. However, nonclinical data suggest potential toxicity in the liver and kidney when creatine is used at high doses. Some data support the 18 potential for creatine to be associated with renal toxicity, particularly in patients who have, or are at risk of, renal impairment. Many mitochondrial disorders are commonly associated with renal impairment and we did not find adequately designed safety evaluations to provide data on which to identify safe doses for mitochondrial disease patients. Reports of trials, clinical evidence, and anecdotal reports of effectiveness, or lack of effectiveness, of the bulk drug substance Treatment Guidelines for Mitochondrial Disorders Treatment for mitochondrial diseases is mostly supportive and determined by phenotypic symptom expression (Kisler et al. Of 32 practitioner respondents, 75% reported that creatine is among their "most often used" vitamins or xenobiotics. It has been emphasized, however, that there is a need to overcome the difficulties associated with "obtaining high-quality evidence for rare disorders" to collect reliable evidence of drug treatment effects (Pfeffer et al. The National Institute of Neurological Disorders and Stroke Common Data Element Project has defined a Mitochondrial Disease Data Standards list to assist researcher in accruing critical and consistent information among studies of mitochondrial disorders (Karaa et al. Patients were crossed over to receive the alternate treatment after a 5 week washout. It is noted that Tarnopolsky and Martin (1999) later reported on creatine supplementation effects in a group of 81 patients with various neuromuscular diseases, but the heterogeneity of this group was too great to assess the impact of creatine on the mitochondrial disease patients (n = 17). No significant differences were observed between treatments for exercise performance (including a variety of assessments of strength, torque, aerobic cycle ergonometry, plasma lactate, ataxia, and symptom scores), eye movements or activities of daily life. The authors found that based on 31P magnetic resonance spectroscopy, creatine treatment showed no effects. In addition, creatine treatment showed no effects on clinical scores or laboratory tests, with the exception that creatine plasma levels were increased during creatine treatment. This retrospective study compared exercise performance prior to treatment and after variable periods of dosing (between 9 months and nearly 5 years). A skeletal muscle power analysis based on cycle ergonometer performance showed an increase in performance compared to baseline of between 4 and 30%. Design considerations of this study, such as lack of a control group, and the variability of patients, doses and treatment duration, limit the ability to generalize from these findings. Creatine has been studied in combination with other agents for the treatment of mitochondrial diseases. The authors conclude that combination therapies may target multiple common pathways of mitochondrial dysfunction, but larger studies of combination therapies in homogeneous populations are needed. Early diagnosis of three of these patients and treatment with creatine beginning at ages 4, 16 and 24 months, respectively, has been associated with normal development. Other patients, who received treatment after the onset of symptoms have continued to have various cognitive and functional disabilities. Treatment with creatine is reported to have improved or restored brain creatine levels and improved a variety of symptoms. At 800 mg/kg/day, one patient was found to have urinary creatine crystals which were reversible upon dose reduction. Treatments consisted of creatine monohydrate (doses of 300 800 mg/kg/day) with various other substances including L-ornithine, sodium benzoate and protein/arginine restricted diets to control brain and plasma levels of related metabolic products. Clinical improvement had been reported in "the majority of patients" across all symptoms. Four were diagnosed after the appearance of symptoms and one was diagnosed at birth. The patient treated from birth remained asymptomatic and was reported to be developmentally normal at 12 months of age. Initial assessment could include a blood spot test followed by genetic sequencing in potentially affected patients (Viau et al. Recommendations for creatine supplementation do not appear in treatment guidelines. The identified biochemical mechanism of action is supported by clearly documented clinical outcomes. Length of time the substance has been used in pharmacy compounding Insufficient information is available to determine how long creatine or creatine monohydrate have been used in pharmacy compounding. Topically, it is used for aging skin (Natural Medicines Comprehensive Database 2018). Results from a Google search using the terms creatine compounding pharmacy indicate that creatine may been included as a component of the "Mito Cocktail," which according to MitoAction,15 is a cocktail16 of various vitamins and supplements commonly used in adults and children who have been diagnosed with mitochondrial disease. Otherwise, we did not find evidence of any compounded creatine or creatine monohydrate products for clinical use in the United States. How widespread its use has been Insufficient data are available from which to draw conclusions about the extent of use of creatine or creatine monohydrate in compounded drug products. Conclusions: Based on internet searches, it appears that creatine is/has been compounded along with various other ingredients into a cocktail for use in patients with mitochondrial disease. After considering the information currently available, a balancing of the criteria weighs in favor of creatine monohydrate solid oral dosage forms being placed on that list based on the following: 1. Creatine monohydrate is easily characterized, and its preparation has been well developed. It is likely to be stable under ordinary storage conditions in its solid form and in solid oral dosage forms when kept away from moisture. However, aqueous formulations, including aqueous oral formulations, are unlikely to be stable. Creatine monohydrate is generally associated with non-serious adverse events, and safe doses have been identified for healthy adults. We did not find adequately designed safety evaluations to provide data with which to identify safe doses for mitochondrial disease patients or other patients having, or at risk of having, renal impairment. Some data support the potential for creatine to be associated with renal toxicity, particularly in patients who have, or are at risk of, renal impairment. Mitochondrial disorders encompass a wide variety of conditions, genetic mutations, and phenotypic presentations. There are no compelling data that establish the effectiveness of creatine monohydrate in the treatment of mitochondrial diseases. It appears that creatine monohydrate is/has been compounded along with various other ingredients into a cocktail for treatment of patients with mitochondrial disease. There is insufficient information available to determine how long creatine had been used in pharmacy compounding. Based on this information the Agency has considered, a balancing of the four evaluation criteria weighs in favor of creatine monohydrate solid oral dosage forms being added to the 503A Bulks List. Diagnostic methods and recommendations for the cerebral creatine deficiency syndromes. American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation 37:73-78. Evaluation of the stability of creatine in solution prepared from effervescent creatine formulations. In sickness and in health: the widespread application of creatine supplementation. Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine 8:298-304. Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project. Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics 10:307-319.
If the party fails to remedy the deficiency within the applicable time limits medicine to prevent cold discount 3ml careprost overnight delivery, subject to section 782(e) of the Act medicine ketoconazole cream buy generic careprost 3ml online, the Department may disregard all or part of the original and subsequent responses medications zanx generic 3ml careprost with amex, as appropriate medicine 44291 3ml careprost with amex. Department ``shall not decline to consider information that is submitted by an interested party and is necessary to the determination but does not meet all applicable requirements established by the administering authority' if the information is timely symptoms xanax overdose cheap 3ml careprost mastercard, can be verified medicine 8 capital rocka careprost 3 ml overnight delivery, is not so incomplete that it cannot serve as a reliable basis, and if the interested party acted to the best of its ability in providing the information. Where all of these conditions are met, the statute requires the Department to use the information if it can do so without undue difficulties. Section 776(b) of the Act further provides that the Department may use an adverse inference in applying the facts otherwise available when a party has failed to cooperate by not acting to the best of its ability to comply with a request for information. Section 776(c) of the Act provides that, when the Department relies on secondary information rather than on information obtained in the course of an investigation or review, it shall, to the extent practicable, corroborate that information from independent sources that are reasonably at its disposal. Secondary information is defined as ``information derived from the petition that gave rise to the investigation or review, the final determination concerning the subject merchandise, or any previous review under section 751 concerning the subject merchandise. In the Initiation Notice, the Department stated that the named companies that wish to qualify for separate-rate status in this proceeding must complete, as appropriate, either a separate rate application or certification. The Department has determined that to have probative value, information must be reliable and relevant. In the investigation, the Department relied upon our pre-initiation analysis of the adequacy and accuracy of the information in the Petition. In accordance with section 772(c)(2)(A) of the Act, where appropriate, we made deductions from the starting price (gross unit price) for foreign inland freight and foreign brokerage and handling. We valued brokerage and handling using a price list of export procedures necessary to export a standardized cargo of goods in India. The price list is compiled based on a survey case study of the procedural requirements for trading a standard shipment of goods by ocean transport in India as reported in ``Doing Business 2010: India' published by the World Bank. We valued truck freight expenses using a per-unit average rate calculated from data on the infobanc Web site. The logistics section of this Web site contains inland freight truck rates between many large Indian cities. We valued inland water freight using price data for barge freight reported in a March 19, 2007, article published in the Hindu Business Line. We valued electricity using the updated electricity price data for small, medium, and large industries, as published by the Central Electricity Authority, an administrative body of the Government of India, in its publication titled ``Electricity Tariff & Duty and Average Rates of Electricity Supply in India,' dated March 2008. These electricity rates represent actual country-wide, publicly-available information on tax-exclusive electricity rates charged to small, medium, and large industries in India. For the preliminary results of this administrative review, the Department is valuing labor using a simple average industry-specific wage rate using earnings and/or wage data reported id. A full description of the industry-specific wage rate calculation methodology is provided in the Factor Valuation Memorandum. Use of Facts Available and Adverse Facts Available Section 776(b) of the Act further provides that the Department may use an adverse inference in applying the facts otherwise available when a party has failed to cooperate by not acting to the best of its ability to comply with a request for information. Fushun Carbon at verification initially provided four maps from the Chinese internet search engine ``Baidu maps' as support for its reported suppliers distance. In our review of these maps, we found that the Baidu map distances differed from the reported distance for these suppliers. However, Fushun Carbon was unable to provide the requested maps during the remaining time at verification. As partial adverse facts available, we are applying the highest monthly material input consumption of this toller to the relevant missing consumption data. Preliminary Results of Review the Department has determined that the following preliminary dumping margins exist for the period August 21, 2008, through January 31, 2010: Weighted-average percent margin Fushun Carbon with regard to this specific information. Interested parties may submit written comments no later than 30 days after the date of publication of these preliminary results of review. Any interested party may request a hearing within 30 days of publication of this notice. If a request for a hearing is made, parties will be notified of the time and date for the hearing to be held at the U. For assessment purposes, we calculated exporter/importer- (or customer) specific assessment rates for merchandise subject to this review. Where appropriate, we calculated a per-unit rate for each importer (or customer) by dividing the total dumping margins for reviewed sales to that party by the total sales quantity associated with those transactions. For Muzi Carbon, a company receiving a separate rate that was not selected for individual review, we will calculate an assessment rate based on the weighted average of the cash deposit rates calculated for the companies selected for individual review consistent with section 735(c)(5)(B) of the Act. These deposit requirements, when imposed, shall remain in effect until further notice. Notification of Interested Parties this notice also serves as a preliminary reminder to importers of their responsibility under section 351. This administrative review and this notice are in accordance with sections 751(a)(1) and 777(i) of the Act, and sections 351. This notice announces membership opportunities for appointment as American representatives to the U. The Forum, consisting of both private and public sector members, brings together leaders of the respective business communities of the United States and Brazil to discuss issues of mutual interest, particularly ways to strengthen the economic and commercial ties between the two countries. The Committee will be composed of two Sections, each consisting of eight to ten members from the private sector, representing the views and interests of the private sector business community in the United States and Brazil. The Committee will provide recommendations to the two governments that reflect private sector views, needs and concerns regarding the creation of an economic environment in which their respective private sectors can partner, thrive, and enhance bilateral commercial ties to expand trade between the United States and Brazil. In addition, the candidate may not be a registered foreign agent under the Foreign Agents Registration Act of 1938, as amended. Applicants may not be federallyregistered lobbyists, and, if appointed, will not be allowed to continue to serve as members of the U. Members will be selected on the basis of who will best carry out the objectives of the Forum as stated in the Terms of Reference establishing the U. Section of the Forum should also include members that represent a diversity of business sectors and geographic locations. Section members also should represent a cross-section of small, medium, and large firms. Individual members will be responsible for all travel and related expenses associated with their participation in the Forum, including attendance at Committee and Section meetings. Only appointed members may participate in official Forum meetings; substitutes and alternates will not be designated. The Department may extend this time limit if it decides that it is reasonable to do so. As noted above, Globe withdrew its request for review of Zhejiang on January 11, 2011. While Globe withdrew its request for an administrative review after the 90-day deadline, the Department has determined that it is reasonable to extend the time for Globe to file a withdrawal of its request for a review of Zhejiang because the review is not at an advanced stage such that significant resources have been expended in conducting the review. Gary Taverman, Acting Deputy Assistant Secretary for Antidumping and Countervailing Duty Operations. The numbers must be of a specific size and format and located at specified locations. In lieu of telephone interviews, respondents may also provide information via faxed logsheets or online via a Web tool. Type of Review: Regular submission (extension of a current information collection). Affected Public: Individuals or households; business or other for-profit organizations. Abstract the Large Pelagic Fishing Survey consists of dockside and telephone surveys of recreational anglers for large pelagic fish (tunas, sharks, and billfish) in the Atlantic Ocean. Assane Diagne, Economist; Gulf of Mexico Fishery Management Council; telephone: (813) 3481630 x233. In addition, the amendment will consider a temporary suspension of income qualification requirements for the renewal of commercial reef fish permits and evaluate modifications to these requirements. The amendment will also consider the elimination of income qualification requirements. Special Accommodations these meetings are physically accessible to people with disabilities. Special Accommodations the meeting is physically accessible to people with disabilities. Requests for sign language interpretation or other auxiliary aids should be directed to Kitty M. Simonds, (808) 5228220 (voice) or (808) 5228226 (fax), at least 5 days prior to the meeting date. The Gulf of Mexico Fishery Management Council will convene a meeting of the Standing, Special Mackerel and Special Reef Fish Scientific and Statistical Committees. Draft agendas and additional information regarding the Commission are available on our Web site: Inquiries regarding the agenda and requests to submit written or oral statements should be addressed to Thomas Luebke, Secretary, U. Individuals requiring sign language interpretation for the hearing impaired should contact the Secretary at least 10 days before the meeting date. The above actions are to assist the Council in preparing a generic amendment to set annual catch limits and accountability measures for stocks under its management. Although other non-emergency issues not on the agenda may come before the Scientific and Statistical Committees for discussion, in accordance with the Magnuson-Stevens Fishery Conservation and Management Act, those issues may not be the subject of formal action during this meeting. Special Accommodations this meeting is physically accessible to people with disabilities. Thompson, Acting Director, Office of Sustainable Fisheries, National Marine Fisheries Service. The need for the proposed action is to provide range capabilities for training and equipping combatcapable naval forces ready to deploy worldwide. Nora Gluch, Naval Facilities Engineering Command, Atlantic, 6506 Hampton Boulevard, Norfolk, Virginia 235081278; telephone: 7573224769. The Director, Information Collection Clearance Division, Regulatory Information Management Services, Office of Management, invites comments on the proposed information collection requests as required by the Paperwork Reduction Act of 1995. Please note that written comments received in response to this notice will be considered public records. Chapter 35) requires that Federal agencies provide interested parties an early opportunity to comment on information collection requests. The Director, Information Collection Clearance Division, Regulatory Information Management Services, Office of Management, publishes this notice containing proposed information collection requests at the beginning of the Departmental review of the information collection. The Department of Education is especially interested in public comment addressing the following issues: (1) Is this collection necessary to the proper functions of the Department; (2) will this information be processed and used in a timely manner; (3) is the estimate of burden accurate; (4) how might the Department enhance the quality, utility, and clarity of the information to be collected; and (5) how might the Department minimize the burden of this collection on the respondents, including through the use of information technology. King, Director, Information Collection Clearance Division, Regulatory Information Management Services, Office of Management. The application collects the necessary bank account information that allows the U. Borrowers who enroll in automatic payment withdrawal receive a repayment incentive in the form of a 0. Borrowers who do not wish to enroll in automatic debiting of all monthly payments may provide bank account information that allows them to authorize electronic debiting of individual monthly loan payments. Copies of the proposed information collection request may be accessed from edicsweb. When you access the information collection, click on ``Download Attachments' to view. Note: this notice includes one absolute priority with two phases, and funding information for each phase of the competition, and two competitive preference priorities within the absolute priority. Deadline for Transmittal of Applications: See the chart in the Award Information section of this notice (Chart). Funding Opportunity Description Purpose of Program: the purposes of the Technology and Media Services for Individuals with Disabilities program are to: (1) Improve results for children with disabilities by promoting the development, demonstration, and use of technology; (2) support educational media services activities designed to be of educational value in the classroom setting to children with disabilities; and (3) provide support for captioning and video description that are appropriate for use in the classroom setting. Ford Federal Direct Loan (Direct Loan) Program: Application for Automatic Withdrawal of Payments. Technology-based approaches for professional development will not be funded under this priority; (3) Provide a detailed plan for conducting work in one of the following two phases: (i) Phase 1-Development: Projects funded under Phase 1 must develop and refine a technology-based approach, and test its feasibility for use with children with disabilities. Activities under Phase 1 of the priority may include development, adaptation, and refinement of technology, materials, or methodologies. Each project funded under Phase 1 must be designed to develop, as its primary product, a promising technology-based approach for which it demonstrates evidence of its usability and feasibility for improving results for children with disabilities. Approaches studied under Phase 2 may have been developed with previous funding under Phase 1 of this priority or with funding from other sources. Phase 2 of this priority is primarily intended to produce sound research-based evidence demonstrating that the technology-based approach can improve educational or early intervention results for children with disabilities in a defined range of real world contexts. Projects funded under Phase 2 of this priority must conduct research that poses a causal question and must seek to answer that question through randomized assignment to treatment and comparison conditions, unless a strong justification is made for why a randomized trial is not possible. If a randomized trial is not possible, the applicant must employ alternatives that substantially minimize selection bias or allow the selection bias to be modeled. These alternatives include appropriately structured regression-discontinuity designs and natural experiments in which naturally occurring circumstances or institutions (perhaps unintentionally) divide people into treatment and comparison groups in a manner akin to purposeful random assignment. In their applications, applicants proposing to use an alternative system must (1) make a compelling case that randomization is not possible, and (2) describe in detail how the procedures will result in substantially minimizing the effects of selection bias on estimates of effect size. Observational, survey, or qualitative methodologies may complement experimental methodologies to assist in the identification of factors that may explain the effectiveness or ineffectiveness of the technology-based approach being evaluated. Applicants must propose research designs that permit the identification and assessment of factors that may have an impact on the fidelity of implementation. Mediating and moderating variables that are both measured in the practice or model condition and are likely to affect outcomes in the comparison condition must be measured in the comparison condition. Projects funded under Phase 2 of this priority must conduct comprehensive research in order to provide convincing evidence of the effectiveness or ineffectiveness of the technology-based approach under study, at least within a defined range of settings. Applicants must provide documentation that available sample sizes, methodologies, and treatment effects are likely to result in conclusive findings regarding the effectiveness of the technology-based approach; (4) Provide a plan for forming collaborative relationships with vendors, other dissemination or marketing resources, or both to ensure that the technology-based approach can be made widely available if sufficient evidence of effectiveness is obtained. Applicants should document the availability and willingness of dissemination or marketing resources to participate. Abstracts of projects funded under these two phases can be found at publicddb.
Ultrasound-guided embryo transfer improves pregnancy rates and increases the frequency of easy transfers ok05 0005 medications and flying cheap careprost 3 ml line. Comparison between two forms of vaginally administered progesterone for luteal phase support in assisted reproduction cycles symptoms 9 weeks pregnant purchase careprost 3 ml line. Luteal phase support using either Crinone 8% or Utrogest: results of a prospective medicine hat mall cheap careprost 3ml with visa, randomized study medicine pacifier safe careprost 3ml. Follicular and luteal phase characteristics following early cessation of gonadotrophin-releasing hormone agonist during ovarian stimulation for in-vitro fertilization medicine wheel colors careprost 3ml without a prescription. The usefulness of ultrasound guidance in frozen-thawed embryo transfer: a prospective randomized clinical trial treatment 4 water cheap careprost 3ml online. A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles. Delaying the initiation of progesterone supplementation results in decreased pregnancy rates after in vitro fertilization: a randomized, prospective study. Optimization of estradiol supplementation during the luteal phase improves the pregnancy rate in women undergoing in vitro fertilization-embryo transfer cycles. Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind, randomized study. Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? Low-dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study. Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial. A randomized, double-blind, placebo-controlled trial of heparin and aspirin for women with in vitro fertilization implantation failure and antiphospholipid or antinuclear antibodies. Treatment of repeated unexplained in vitro fertilization failure with intravenous immunoglobulin: a randomized, placebo-controlled Canadian trial. Assessment of uterine cavity by hysteroscopy in assisted reproduction programme and its influence on pregnancy outcome. Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis. Inclusion of standard and low-dose gonadotropin releasing hormone-analog (short protocol) in controlled ovarian hyperstimulation regimens in normogonadotropic patients aged 40-48 years who are undergoing in vitro fertilization. Periimplantation glucocorticoid administration for assisted reproductive technology cycles [Full Review]. Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome [Full Review]. Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis. A prospective randomized trial of conventional in vitro fertilization versus intracytoplasmic sperm injection in unexplained infertility. Short coincubation of gametes in in vitro fertilization improves implantation and pregnancy rates: a prospective, randomized, controlled study. Rigorous thermal control during intracytoplasmic sperm injection stabilizes the meiotic spindle and improves fertilization and pregnancy rates. Surgical treatment for tubal disease in women due to undergo in vitro fertilisation [Full Review]. Intravenous albumin versus hydroxyethyl starch for the prevention of ovarian hyperstimulation in an invitro fertilization programme: a prospective randomized placebo controlled study. Implantation failures: success of assisted hatching with quarter-laser zona thinning. A European multicentre prospective randomized study to assess the use of assisted hatching with a diode laser and the benefit of an immunosuppressive/antibiotic treatment in different patient populations. A randomized double-blind controlled study of the efficacy of laser-assisted hatching on implantation and pregnancy rates of frozen-thawed embryo transfer at the cleavage stage. Utilization of high-security straws for embryo freezing in an in vitro fertilization program: a prospective, randomized study. Zona thinning with noncontact diode laser in patients aged < or = 37 years with no previous failure of implantation: a prospective randomized study. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. Blastocyst culture and transfer: a step toward improved in vitro fertilization outcome. Blastocyst-stage embryo transfer in patients who failed to conceive in three or more day 2-3 embryo transfer cycles: a prospective, randomized study. Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. Embryo transfer is equally effective at cleavage stage and blastocyst stage: a randomized prospective study. Impact of assisted hatching on the outcome of intracytoplasmic sperm injection: a prospective, randomized clinical trial and pregnancy follow-up. Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection [Full Review]. Cleavage stage versus blastocyst stage embryo transfer in assisted conception [Full Review]. Zygote transfer on day 1 versus cleavage stage embryo transfer on day 3: a prospective randomized trial. A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial. Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. Are children born after assisted reproductive technology at increased risk for adverse health outcomes? Spontaneous embryonic loss following in vitro fertilization: incidence and effect on outcomes. Pregnancy loss among pregnancies conceived through assisted reproductive technology, United States, 1999-2002. Polycystic ovarian syndrome and the risk of spontaneous abortion following assisted reproductive technology treatment. Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection. Secondtrimester maternal serum screening for Down syndrome in in vitro fertilization pregnancies. Medically assisted reproduction and second-trimester maternal serum marker screening for Down syndrome. Nuchal translucency measurement and pregnancy outcome after assisted conception versus spontaneously conceived twins. Are singleton assisted reproductive technology pregnancies at risk of prematurity? Impact of infertility characteristics and treatment modalities on singleton pregnancies after assisted reproduction. Birthweight of singletons after assisted reproduction is higher after single- than after double-embryo transfer. Pregnancy outcomes from in-vitro fertilisation and intracytoplasmic sperm injection: a comparison. Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilizationembryo transfer or gamete intrafallopian transfer: a meta-analysis. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Perinatel outcomes of singleton pregnancies achieved by in vitro fertilization: a systematic review and metaanalysis. Twin pregnancy outcome among cases of spontaneous conception, intrauterine insemination, and in vitro fertilization/intracytoplasmic sperm injection. Comparison of obstetric outcomes in twin pregnancies after in vitro fertilization, ovarian stimulation and spontaneous conception. Obstetric outcome of twin pregnancies after in-vitro fertilization: a matched control study in four Dutch university hospitals. Pregnancy outcome in spontaneous twins versus twins who were conceived through in vitro fertilization. Preeclampsia in multiple gestation: the role of assisted reproductive technologies. Risk of cesarean section in singleton pregnancies after assisted reproductive techniques. Relationships and parenthood in couples after assisted reproduction and in spontaneous primiparous couples: a prospective long-term follow-up study. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Children born after assisted fertilization have an increased rate of major congenital anomalies. Neonatal outcome and congenital malformations in children born after in-vitro fertilization. The prevalence of major congenital malformations during two periods of time, 1986-1994 and 1995-2002 in newborns conceived by assisted reproduction technology. Very low-birth-weight-infants conceived by in vitro fertilization are not at higher risk for mortality and morbidity: a population-based study. Perinatal outcomes of in vitro fertilization twins: a systematic review and meta-analyses. Neurological sequelae in children born after in-vitro fertilisation: a population-based study. Potential association between infertility and spinal neural tube defects in offspring. Reproductive factors, subfertility, and risk of neural tube defects: a case-control study based on the Oxford Record Linkage Study Register. A prospective controlled study of karyotyping for 430 consecutive babies conceived through intracytoplasmic sperm injection. Two-year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study. Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study. Cancer incidence in a cohort of infertile women who underwent in vitro fertilization. Breast cancer risk associated with being treated for infertility: results from the French E3N cohort study. A casecontrol study of ovarian cancer in relation to infertility and the use of ovulation-inducing drugs. Association of oral contraceptive use, other contraceptive methods, and infertility with ovarian cancer risk. Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies. Assisted reproductive technology and the incidence of ovarian cancer: a meta-analysis. Psychosocial risks associated with multiple births resulting from assisted reproduction. Parenting stress in first-time mothers of twins and triplets conceived after in vitro fertilization. Comparison of child-rearing problems between mothers with multiple children who conceived after infertility treatment and mothers with multiple children who conceived spontaneously. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Discrepancies between meta-analyses and subsequent large randomized, controlled trials. Assisted conception is a risk factor for postnatal mood disturbance and early parenting difficulties. Population-based investigations to study the association of cardiovascular polymorphisms and adverse pregnancy outcome. Long term mortality of mothers and fathers after preeclampsia: population based cohort study. Treatment preferences and trade-offs for ovulation induction in clomiphene citrate-resistant patients with polycystic ovary syndrome. Evidence of improving quality of reporting of randomized controlled trials in subfertility. Obstetric outcome of twin pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously. A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation. Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases. Comparison of unilateral and bilateral transfer of injected oocytes into fallopian tubes: a prospective, randomized clinical trial. Prospective randomized comparison of Wallace and Labotect embryo transfer catheters. Inclusion of standard and low-dose gonadotropin releasing hormoneanalog (short protocol) in controlled ovarian hyperstimulation regimens in normogonadotropic patients aged 40-48 years who are undergoing in vitro fertilization. Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial.
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